A study of altered resting-state functional connectivity strength in depressed schizophrenia

GUO Li-ning1; ZHUO Chuan-jun2; QIN Wen1; YU Chun-shui1

doi:10.12117/jccmi.2018.08.006

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Journal of China Clinic Medical Imaging ›› 2018, Vol. 29 ›› Issue (8) : 552-555. DOI: 10.12117/jccmi.2018.08.006

A study of altered resting-state functional connectivity strength in depressed schizophrenia

GUO Li-ning1, ZHUO Chuan-jun2, QIN Wen1, YU Chun-shui1

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Abstract

Objective: To investigate functional connectivity strength(FCS) changes underlying depressive symptoms in patients with schizophrenia(SZ) and to analyze correlation depressive symptoms with FCS. Methods: Ninety-one SZ patients and 89 healthy controls(HC) were recruited to undergo a resting-state functional magnetic resonance imaging. The positive and negative symptom scale(PANSS) general psychopathology scale item 6(G6) was used to assess the severity of depressive symptoms in SZ. Patients were defined as depressed with scores of PANSS-G6>1, otherwise they were categorized into the non-depressed group(NDSZ). The correlation between FCS and depression severity was tested using multiple regression analysis in SZ. The FCS maps correlated with the depression symptoms were compared with one-way ANOVA among the three groups. Results: Depressive scores were strongly correlated with FCS values in the bilateral superior temporal gyrus(STG) in SZ patients. The FCS values in the bilateral STG were significantly increased in DSZ compared to NDSZ and HC. Conclusion: Schizophrenia patients with depressive symptoms have stronger FCS in the bilateral STG, which may be a possible neural mechanism of the depressive symptoms in these patients.

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Schizophrenia / Depressive disorder / Magnetic resonance imaging

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GUO Li-ning1, ZHUO Chuan-jun2, QIN Wen1, YU Chun-shui1. A study of altered resting-state functional connectivity strength in depressed schizophrenia[J]. Journal of China Clinic Medical Imaging. 2018, 29(8): 552-555 https://doi.org/10.12117/jccmi.2018.08.006

References

[1]Buckley PF, Miller BJ, Lehrer DS, et al. Psychiatric comorbidities and schizophrenia[J]. Schizophr Bull, 2009, 35(2): 383-402.
[2]Moller HJ. Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: conceptual and treatment issues[J]. World J Biol Psychiatry, 2005, 6(4): 247-263.
[3]Sands JR, Harrow M. Depression during the longitudinal course of schizophrenia[J]. Schizophr Bull, 1999, 25(1): 157.
[4]Sim K, Mahendran R, Siris SG, et al. Subjective quality of life in first episode schizophrenia spectrum disorders with comorbid depression[J]. Psychiatry Res, 2004, 129(2): 141-147.
[5]Siris SG, Addington D, Azorin JM, et al. Depression in schizophrenia: recognition and management in the USA[J]. Schizophr Res, 2001, 47(2-3): 185-197.
[6]Fenton WS. Depression, suicide, and suicide prevention in schizophrenia[J]. Suicide Life Threat Behav, 2000, 30(1): 34-49.
[7]Zisook S, Mcadams LA, Kuck J, et al. Depressive symptoms in schizophrenia[J]. Am J Psychiatry, 1999, 156(11): 1736-1743.
[8]Tomasi D, Wang GJ, Volkow ND. Energetic cost of brain functional connectivity[J]. Proc Natl Acad Sci USA, 2013, 110(33): 13642-13647.
[9]Wang L, Dai Z, Peng H, et al. Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect[J]. Hum Brain Mapp, 2014, 35(4): 1154-1166.
[10]Yan CG, Wang XD, Zuo XN, et al. DPABI: Data Processing & Analysis for(Resting-State) Brain Imaging[J]. Neuroinformatics, 2016, 14(3): 339-351.
[11]Arnsten AF, Rubia K. Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders[J]. J Am Acad Child Adolesc Psychiatry, 2012, 51(4): 356-367.
[12]Caetano SC, Hatch JP, Brambilla P, et al. Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression[J]. Psychiatry Res, 2004, 132(2): 141-147.
[13]Jou RJ, Minshew NJ, Keshavan MS, et al. Enlarged right superior temporal gyrus in children and adolescents with autism[J]. Brain Res, 2010, 1360: 205-212.
[14]Allison T, Puce A, Mccarthy G. Social perception from visual cues: role of the STS region[J]. Trends Cogn Sci, 2000, 4(7): 267-278.
[15]Gallagher HL, Frith CD. Functional imaging of ‘theory of mind’[J]. Trends Cogn Sci, 2003, 7(2): 77-83.
[16]Takahashi T, Malhi GS, Wood SJ, et al. Gray matter reduction of the superior temporal gyrus in patients with established bipolar Ⅰ disorder[J]. J Affect Disord, 2010, 123(1-3): 276-282.
[17]Abe O, Yamasue H, Kasai K, et al. Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression[J]. Psychiatry Res, 2010, 181(1): 64-70.
[18]Fitzgerald PB, Laird AR, Maller J, et al. A meta-analytic study of changes in brain activation in depression[J]. Hum Brain Mapp, 2008, 29(6): 683-695.
[19]Rive MM, Van Rooijen G, Veltman DJ, et al. Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies[J]. Neurosci Biobehav Rev, 2013, 37(10 Pt 2): 2529-2553.
[20]Valente KD, Busatto Filho G. Depression and temporal lobe epilepsy represent an epiphenomenon sharing similar neural networks: clinical and brain structural evidences[J]. Arq Neuropsiquiatr, 2013, 71(3): 183-190.
[21]Glosser G, Zwil AS, Glosser DS, et al. Psychiatric aspects of temporal lobe epilepsy before and after anterior temporal lobectomy[J]. J Neurol Neurosurg Psychiatry, 2000, 68(1): 53-58.