WU Dan, REN Wei-dong, TAN Xue-ying, SONG Guang
Objective: To explore the value of real-time three-dimensional speckle tracking imaging(RT3D-STI) in the evaluation of left ventricular myocardial strain in left breast cancer patients treated with radiotherapy in early stage. Methods: Totally 37 cases of left breast cancer patients with radiotherapy underwent three dimensional echocardiography. Left ventricular diastolic volume(LVEDV), left ventricular systolic volume(LVESV), left ventricular ejection fraction(LVEF), cardiac output(CO), left ventricular sphericity index(SpI), etc, and left ventricular global longitudinal strain (GLS), left ventricular global circumferential strain(GCS), left ventricular area strain(GAS), left ventricular radial strain(GRS) were acquired by RT3D-STI before and after radiotherapy respectively. The differences of parameters between the two groups were compared. Results: There was no significant difference in LVEDV, LVESV, SV, CO, end-diastolic mass(EDmass), end-systolic mass(ESmass), SpI between the two groups(P>0.05), LVEF was significantly reduced((59.47±4.47) vs. (63.20±4.86), r=2.48, P<0.05). GLS, GCS, GAS, GRS were all decreased after radiotherapy(P<0.05), especially GAS. The correlation coefficients of GLS, GCS, GAS and GRS were r=-0.710, r=-0.645, r=-0.814, respectively(P<0.05), GAS was closely related to GRS. The correlation coefficients of GLS, GCS, GAS, GRS and LVEF were r=-0.653, r=-0.627, r=-0.724, r=0.693, respectively. GAS was closely related to LVEF. Conclusion: In the early stage of the radiotherapy of left breast cancer, RT3D-STI can accurately provide the changes of specific parameters of left ventricular systolic function in different directions when the results of general parameters are in the normal range, and the changes of gas parameters are more valuable, so as to assist clinicians to evaluate the heart damage of patients in the early stage of radiotherapy.
