Objective: To investigate the integrity of executive control network(ECN), frontoparietal network(FPN) in type 2 diabetic patients by using independent component analysis(ICA), and to explore the relationship between network abnormalities, neurocognitive performance and glycaemic indices. Methods: Multidimensional cognitive function tests and rs-fMRI scans were performed in 23 T2DM patients and 25 healthy controls. Statistical analysis was conducted using REST-statistical analysis and the SPSS software. Results: Patients performed significantly worse on the MoCA, TMT-B, CFT, CFT-delayed recall and DST tests, which mainly involved cognitive domains of executive function, processing speed and spatial episodic memory. Compared with the healthy controls, patients showed decreased FC in the left parietal lobe, cingulate gyrus, right frontal lobe of ECN; increased FC in the right inferior frontal gyrus and middle frontal gyrus, decreased FC in the right postcentral gyrus of r-FPN; decreased FC in the left parietal lobe of l-FPN. Correlation analysis showed decreased connectivity in the right frontal lobe was significantly correlated with the insulin resistance level(P=0.046, r=-0.420). FC strength in the ECN and FPN was negative correlated with the neurocognitive performance. Conclusion: T2DM group manifests cognitive impairments of executive function, processing speed and spatial episodic memory and have a slective defects of ECN, FPN on right and FPN on left. The disrupted pattern of resting-state ECN was associated with IR in T2DM patients.
Key words
Diabetes mellitus, type 2 /
Magnetic resonance imaging
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