Objective: To study the imaging manifestations of parathyroid carcinoma. Methods: Ultrasonography, 99mTc-MIBI SPECT/CT(or SPECT), MRI findings and 18F-FDG PET/CT of 6 patients with parathyroid carcinoma confirmed pathologically were analyzed retrospectively, and reviewing relevant literatures. Results: Ultrasonography findings: The average maximum diameter of 6 lesions was 27.7 mm; 6 cases manifested hypoechonic, 2 of which had mirocalcifications; 3 cases showed sharp in grey scale while 3 cases presented blurred nodular margin; 4 cases had a little blood flow while 2 cases with rich blood flow. 99mTc-MIBI SPECT/CT(or SPECT) findings: 3 cases were positive and 3 cases were negative; On CT imaging, 2 cases contained microcalcifications. On MRI, 1 case showed slight low signals on T1WI and slight hyperintensity signals on T2WI, and hyperintensity signal on T1-weighted sequence. One case of postoperative 18F-FDG PET/CT found intensely high FDG uptake in multiple bones(range of SUVmax: 2.5～8.8) with osteolytic destruction and soft tissue mass. Conclusion: The imaging findings of parathyroid carcinomas have certain features. Heterogeneous intensity, microcalcifications, blurred nodular marginare helpful for diagnosis of parathyroid carcinoma. MRI can clearly manifest the relationship between adjacent tissues. 18F-FDG PET/CT is contributed to restaging, evaluation of postsurgery and follow-up of parathyroid carcinoma.
Key words
Parathyroid neoplasms /
Ultrasonography /
Tomography, emission-computed, single-photon; /
Positron-emission tomography /
Magnetic resonance imaging
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