Objective: To evaluate dual energy CT(DECT) diagnostic ability on nonalcoholic fatty liver disease/steatohepatitis(NAFLD/NASH), by comparing the DECT results with histopathology. Materials and Methods: Seventy Rhesus monkeys(Age >7 years, BW >7 kg, HBV and HCV negative) underwent ultrasound examination, among them 19 monkeys with moderate steatosis and 12 with mild steatosis and 6 normal monkeys took DECT examination, and within two weeks after DECT, ultrasound guided biopsy was done on 10 moderate and 8 mild steatosis and 6 normal monkeys. Results: HU100 kVp/Sn140 kVp, ΔHUSn140-100 kVp and ΔHULv-Sp（50 keV） were 0.95±0.04, (2.8±2.1) HU, (-16.4±6.3) HU; 1.02±0.03, (-0.7±1.3) HU, (-6.8±5.0) HU and 1.11±0.01, (-6.2±0.4) HU, (7.5±1.8) HU respectively. These results showed strong correlation with histopathology(R=-0.57, P<0.01; R=0.54, P<0.01; R=-0.71, P<0.001). Conclusion: The diagnostic results of DECT and the pathological results have a good consistency. As a noninvasive method, DECT showed great capacity on NAFLD diagnosis.
Key words
Fatty liver /
Monkey diseases /
Tomography, X-ray computed /
Ultrasonography
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