Application of 18F-FDG PET/CT in IgG4-related diseases

doi:10.12117/jccmi.2019.12.009

Journal of China Clinic Medical Imaging ›› 2019, Vol. 30 ›› Issue (12) : 875-880. DOI: 10.12117/jccmi.2019.12.009

PET Center, Nanfang Hosptial, Southern Medical University, Guangzhou 510515, China

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Abstract

Objective: To investigate the application of 18F-FDG PET/CT in IgG4-related diseases(IgG4-RD). Methods: This study retrospectively analyzed 47 cases of IgG4-RD diagnosed according to the comprehensive diagnostic criteria of IgG4-RD. The data of clinical information and 18F-FDG PET/CT presentation were collected and analyzed. Results: Of the 47 IgG4-RD patients, male was predominant(35/47, 74.47%) and the average age was 47.51 years(range 23~79 years). Forty-three cases displayed multiple organs involvement, and lymph nodes(29/47), pancreas(27/47) and salivary glands(16/47) were more common. All the involved lesions displayed high FDG uptake, and in which the salivary gland was the highest uptake(SUVmax 6.44±4.98), followed by lymph nodes and pancreas. 81.58% of the patients(31/38) involved the exocrine glands exhibiting symmetrical or diffuse gland swelling with increased homogeneous or heterogeneous metabolism. According to the grouping analysis of serum IgG4 elevation, the elevated IgG4 group was more prone to eosinophil elevation, prostate involvement, higher uptake of involved lacrimal gland and pancreas, and more sensitive to hormone therapy(All P<0.05). In the effective follow-up of 41 cases, 65.85% of patients were sensitive to hormone therapy. Although the serum IgG4 level was not significantly decreased after treatment, the 18F-FDG uptake of the involved lesions was significantly reduced. Conclusion: PET/CT is of great value in the diagnosis and differential diagnosis of IgG4-RD, the choice of biopsy site, the assessment of systemic organ involvement, and the monitoring of therapeutic effect.

Key words

Immunoglobulin G / Fluorodeoxyglucose F18 / Positron-emission tomography

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PET Center, Nanfang Hosptial, Southern Medical University, Guangzhou 510515, China. Application of 18F-FDG PET/CT in IgG4-related diseases[J]. Journal of China Clinic Medical Imaging. 2019, 30(12): 875-880 https://doi.org/10.12117/jccmi.2019.12.009

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