Experimental studies of infection imaging of CPF labeled with 99mTc

ZHANG Hong; JIANG Ning-yi; ZHU Lin; LI Hong-yu; LIU Xiong-ying; CHEN Gui-bing; CHEN Shao-xiong

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (1) : 42-44.

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Experimental studies of infection imaging of CPF labeled with 99mTc

ZHANG Hong1, JIANG Ning-yi1, ZHU Lin2, LI Hong-yu1, LIU Xiong-ying1, CHEN Gui-bing1, CHEN Shao-xiong1

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Abstract

Objective: To prepare 99mTc-Ciprofloxacin(CPF), an inflammation tracer, and obtain the information about its biodistribution and scintigraphy in mice model, and assess its feasibility of clinical application. Methods: The stability of 99mTc-CPF, its biodistribution in mice model were studied, and 99mTc-CPF scintigraphy in mice model of inflammation was also performed. Results: The labelling rate of 99mTc-CPF was over 90%. 99mTc-Ciprotech was stable within 6 hours at room temperature. The inflammatory tissue/normal tissue were 3.48, 4.30 and 4.17 at 1, 4, 6 hour after injection respectively. The radioactivity clearance mainly occurred in the liver and kidney, and the clearance from blood was rapid. Conclusion: 99mTc-CPF is a specific and sensitive radiophamiaceutical agent for scintigraphy of inflammatory lesions, and it is easy to prepare.

Key words

Ciprofloxacin / inflammation / radionuclide imaging

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ZHANG Hong;JIANG Ning-yi;ZHU Lin;LI Hong-yu;LIU Xiong-ying;CHEN Gui-bing;CHEN Shao-xiong. Experimental studies of infection imaging of CPF labeled with 99mTc[J]. Journal of China Clinic Medical Imaging. 2006, 17(1): 42-44