The relationship between 99mTc-MIBI breast cancer imaging andthe expression of multidrug resistance-associated protein and Ki-67

LIN Kai-wen; LIU Bao-ping; CHENG Bing

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (10) : 554-556.

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The relationship between 99mTc-MIBI breast cancer imaging andthe expression of multidrug resistance-associated protein and Ki-67

LIN Kai-wen1, LIU Bao-ping2, CHENG Bing2

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Abstract

Objective: To investigate the relationship between 99mTc-MIBI breast imaging results and expression of the drug resistance proteins[multidrug resistance-associated protein(MRP), Ki-67] in human breast cancer tissues. Methods: Thirty-six patients with untreated breast cancer were studied prospectively a week before their surgical operations. They were all injected intravenously with 740MBq 99mTc-MIBI in the arm contralateral to the lesion. Anterior planar images were acquired at 10 and 180 minutes after injection and radioactive washout indices(WI) were calculated. MRP, Ki-67 expression was investigated by immunohistochemical studies on multiple nonconsecutive sections of surgical samples. The differences of the tumor radioactive WI between MRP positive and negative groups, Ki-67 positive and negative groups were compared with. Results: The WI were significantly higher in 13 patients with positive MRP expression when compared with 23 patients with negative MRP expression(16.72±10.17 and 1.76±2.38, P<0.005). However, the differences of WI between the patients with positive and negative Ki-67 expressions were not significant?穴12.47±11.26 and 13.06±12.63, P>0.50). Conclusions: A strong positive correlation was found between the WI of 99mTc-MIBI from the lesions and expression of MRP in untreated breast cancer patients(r=0.783, P<0.001). The WI of 99mTc-MIBI breast imaging may be a useful method for evaluating MRP expression in breast cancer. No significant relationship between 99mTc-MIBI breast imaging results and Ki-67 was found.

Key words

breast neoplasms / technetium tc 99m sestamibi / radionuclide imaging

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LIN Kai-wen;LIU Bao-ping;CHENG Bing. The relationship between 99mTc-MIBI breast cancer imaging andthe expression of multidrug resistance-associated protein and Ki-67[J]. Journal of China Clinic Medical Imaging. 2006, 17(10): 554-556