C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA

JIN Rong; LI Yan-min; CUI Zhuang; JIAO Tong; GAO Wei-ping

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (10) : 566-568.

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C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA

JIN Rong1, LI Yan-min1, CUI Zhuang2, JIAO Tong1, GAO Wei-ping2

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Abstract

Objective: To evaluate the relationship between C-erbB-2, MVD expressions in ovarian tumors and the blood flow of CPA. Methods: Fifty cases of ovarian tumors were examined preoperatively by CPA whereas C-erbB-2 and MVD were stained with immunohistochemistry after operation. Results: The positive expression rate of C-erbB-2 in malignant ovarian tumors was 83.33% which was higher than that in the benign group(30%, P<0.05), the MVD value of malignant ovarian tumors showed positive correlation to the degree of CPA(r=0.823, P<0.05), the MVD value(53.37±7.91) in the positive C-erbB-2 groups including benign and malignant ovarian tumors was higher than that in negative C-erbB-2 group(38.93±3.19, P<0.05). MVD in the malignant ovarian tumors(48.84±6.19) was higher than that in the benign group(20.90±2.71, P<0.05). Their MVD demonstrated a positive correlation to the degree of CPA. The RI value of malignant group(0.36±0.06) was significantly lower than that of the benign group(0.68±0.07, P<0.05). RI values and MVD showed negative correlation(r=-0.806, P<0.05). Conclusion: The expressions of C-erbB-2 and MVD for ovarian tumors support CPA pathologically and the latter provides in turn the sensitive blood flow information for diagnosis of benign and malignant ovarian tumors in clinic.

Key words

ovarian neoplasms / ultrasonography / Doppler / color

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JIN Rong;LI Yan-min;CUI Zhuang;JIAO Tong;GAO Wei-ping. C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA[J]. Journal of China Clinic Medical Imaging. 2006, 17(10): 566-568