Experimental study of the correlation between 99mTc-HL91 hypoxia imagingand expression of HIF-1α in breast carcinoma

SONG Wu-zhan; WANG Jing; CHI Jun; WANG Xi-qing; WANG Yun-ya; WANG Ying

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (10) : 569-571.

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Experimental study of the correlation between 99mTc-HL91 hypoxia imagingand expression of HIF-1α in breast carcinoma

SONG Wu-zhan1, WANG Jing1, CHI Jun2, WANG Xi-qing1, WANG Yun-ya1, WANG Ying1

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Abstract

Objective: To study the 99mTc-HL91 hypoxia imaging in breast carcinoma and correlation between 99mTc-HL91 uptake and expression of HIF-1α. Methods: Thirty-one patients with primary breast carcinoma diagnosed by fine needle aspiration were underwent 99mTc-HL91 hypoxia imaging. Regions of interest(ROI) were drawn on the tumor(T) and contralateral normal breast tissue(NT), T/NT ratios were measured for all scans. The expression of HIF-1α was detected by immunohistochemical method. Results: In all the 31 patients, 99mTc-HL91 uptake of tumor tissue was obviously higher than that of normal tissue, and no relevance to the tumor size(P>0.05). Four hours after injecting 99mTc-HL91, the T/TN of infiltrating ductal carcinoma(IDC) and infiltrating lobular carcinoma(ILC) were 2.16±O.38 and 2.10±0.32 respectively(P>0.05?). In all the 31 patients’ T/NT ratio ranged from 1.36 to 6.43(median: 2.95), the percentage of tumor cells expressing HIF-1α was 25.6%~78.5%(median: 56.3%), and a positive correlation was found between them(P<0.01). Conclusion: The tissue of breast carcinoma can uptake 99mTc-HL91 obviously and has no relevance to pathologic type and tumor size, but expresses a positive correlation with HIF-1α.

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breast neoplasms / radionuclide imaging

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SONG Wu-zhan;WANG Jing;CHI Jun;WANG Xi-qing;WANG Yun-ya;WANG Ying. Experimental study of the correlation between 99mTc-HL91 hypoxia imagingand expression of HIF-1α in breast carcinoma[J]. Journal of China Clinic Medical Imaging. 2006, 17(10): 569-571