Bcl-2 expression in osteosarcoma after chemotherapy: correlation with radiographic change and prognosis

CAI Yi

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (3) : 140-142.

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Bcl-2 expression in osteosarcoma after chemotherapy: correlation with radiographic change and prognosis

CAI Yi

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Abstract

Objective: To correlate bcl-2 expression after chemotherapy in osteosarcoma with radiographic change and prognosis. Methods: Large dose of MMIA chemotherapy was given to 23 patients with pathologically proved osteosarcoma preoperatively. Bcl-2 was examined using immunohistology chemistry before and after chemotherapy. Expression of bcl-2 was correlated with change of radiography and prognosis. Results: Bcl-2 was positive in 73.9% and 39.1% of patients before and after chemotherapy respectively. There was a statistically difference between the two groups. Mean score of radiography before chemotherapy was statistically higher than that after chemotherapy, which was 5.96 scores and 8.65 scores respectively. In 12 patients with good prognosis, bcl-2 was positive in 33.3% and 8.3% before and after chemotherapy respectively. While that in patients with bad prognosis was 44.4% and 33.3% respectively. Conclusion: Expression of bcl-2 after chemotherapy decreased compared to that before chemotherapy. Osteosarcoma with less expression of bcl-2 had a higher score of radiograph and better prognosis.

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osteosarcoma / drug therapy / genes / bcl-2 / radiography

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CAI Yi. Bcl-2 expression in osteosarcoma after chemotherapy: correlation with radiographic change and prognosis[J]. Journal of China Clinic Medical Imaging. 2006, 17(3): 140-142