Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma

YE Jing; XU Yi-kai; LIU Xian; LU Xue-song; XU Peng-jun; HUANG Qi-liu; JIANG Zhi-qiang; LV Guo-shi

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (3) : 167-170.

论著

Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma

YE Jing1, XU Yi-kai1, LIU Xian2, LU Xue-song1, XU Peng-jun1, HUANG Qi-liu1, JIANG Zhi-qiang1, LV Guo-shi1

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Abstract

Objective: To investigate MR enhancement of different administration routes in MR pretargeting immunology imaging. Methods: Two groups of mice were injected with SA-DTPA-Gd through tail vein(iv) and intra-peritoneal cavity(ip) respectively, and the MR signal intensity of tumor and liver was determined. Result: In iv group and ip group the maximum enhancement rate of tumor was 70.2% and 46.4% respectively, and there was significant difference. The maximum enhancement rate of liver was 23.7% in ip group and 20.4% in iv group, and there was no signifinant difference. Conclusion: Intravenous injection is in favor of SA-DTPA-Gd’s accumlation in tumor than intraperitoneal injection, and a more homogenious intratumoral distribution is archived.

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colonic neoplasms / animals testing alternatives / magnetic resonance imaging

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YE Jing;XU Yi-kai;LIU Xian;LU Xue-song;XU Peng-jun;HUANG Qi-liu;JIANG Zhi-qiang;LV Guo-shi. Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma[J]. Journal of China Clinic Medical Imaging. 2006, 17(3): 167-170