Preliminary clinical study in side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease

CHEN Gui-bing; JIANG Ning-yi; LIU Sheng; LU Xian-ping; LIANG Jiu-gen; ZHANG Hong; WU Hua

Journal of China Clinic Medical Imaging ›› 2006, Vol. 17 ›› Issue (7) : 372-375.

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Preliminary clinical study in side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease

CHEN Gui-bing1, JIANG Ning-yi2, LIU Sheng2, LU Xian-ping2, LIANG Jiu-gen2, ZHANG Hong2, WU Hua1

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Abstract

Objective: The aims of this study were to evaluate the side effect and diagnostic value of adenosine ²⁰¹Tl myocardial perfusion imaging for detecting coronary artery disease(CAD). Methods: A total of 21 patients with suspected CAD were submitted with adenosine stress myocardial perfusion imaging. Adenosine was injected by minipump(140 microgram per kg body weight per minute). The total time of adenosine infusion was 6 minutes. At the third minute of adenosine infusion, a bolus of 1.295×10⁸Bq thallium-201 was injected, and SPECT acquisition of burden imaging was obtained at 2 minutes after completion of adenosine infusion. After 2~4 hours redistribution imaging was obtained. Coronary angiography (CAG) was performed in all patients within 2 weeks. Results: In adenosine stress myocardial perfusion imaging, the sensitivity, specificity, positive predictive value, negative predictive value, accuracy were 92.86%, 57.14%, 81.25%, 80.0%, 80.95% respectively. The positive diagnostic rate of single, two and three branches lesions were 83.33%, 100% and 100% respectively. Total positive diagnostic rate was 92.86%. Conclusion: Domestic adenosine stress myocardial perfusion imaging is a safe and reliable diagnostic method for CAD. It has mild side effects, high sensitivity and accuracy in CAD diagnosis.

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coronary disease / radionuclide imaging / adenosine

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CHEN Gui-bing;JIANG Ning-yi;LIU Sheng;LU Xian-ping;LIANG Jiu-gen;ZHANG Hong;WU Hua. Preliminary clinical study in side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease[J]. Journal of China Clinic Medical Imaging. 2006, 17(7): 372-375