Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology

YANG Hong-yan; XU Yi-kai; WU Yuan-kui; LIU Wen-yuan; LV Guo-shi; CAO Guo-hong

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Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (10) : 710-715.

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Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology

YANG Hong-yan1, XU Yi-kai2, WU Yuan-kui2, LIU Wen-yuan3, LV Guo-shi2, CAO Guo-hong2

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Abstract

Objective: To establish a rodent model of VX2 tumor in spleen of rats. To analyze relationship between the change of the signal intensity on superparamagnetic iron oxide(SPIO) enhanced MR images and pathologic change. To discuss the value of SPIO enhanced detection in splenic metastasis in rat. Methods: Eight rodent model of VX2 tumor in spleen was established successfully. The images were obtained before and after administration of superparamagnetic iron oxide. T1-weighted spin-echo(SE) pulse sequence with a repetition time (TR) of 450ms, and echo time(TE) of 12ms(TR/TE=450/12) were performed. The imaging parameters of T2-weighted SE pulse sequence as follows: TR/TE=4000/128. Results: On SPIO enhancement T2WI sequence the SI of splenic parachyma decreased obviously with percentage of signal intensity loss(PSIL) was 55.04%, but the SI of tumor was not evidently change with PSIL was 0.87%. Nevertheless the SNR of normal splenic parenchyma around the lesions had obvious difference(P<0.001) comparatively. The contrast-to-noise(CNR) between VX2 tumor and splenic parenchyma had an evidently difference with before and after admininstration of SPIO(P<0.001). Conclusions: On SPIO enhanced T2WI the contrast degree of lesions increased obviously. Consequently, SPIO-enhanced T2WI MRI scanning can improve the rate of detection and characterization in lesions of spleen.

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splenic neoplasms / models / animal / magnetic resonance imaging

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YANG Hong-yan;XU Yi-kai;WU Yuan-kui;LIU Wen-yuan;LV Guo-shi;CAO Guo-hong. Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology[J]. Journal of China Clinic Medical Imaging. 2007, 18(10): 710-715