Application of 11C-Choline PET/CT in radiotherapy planning of brain tumor

HUANG Zhe-min; GUAN Yi-hui; ZHAO Jun; ZUO Chuan-tao; HUA Feng-chun

Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (11) : 781-784.

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Application of ¹¹C-Choline PET/CT in radiotherapy planning of brain tumor

HUANG Zhe-min, GUAN Yi-hui, ZHAO Jun, ZUO Chuan-tao, HUA Feng-chun

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Abstract

Objective: To investigate the possibility and the methodology of integrating 11C-Choline PET/CT with 3D-CRT/IMRT treatment planning of brain tumors. Methods: Thirty-four consecutive patients presenting with various intracranial tumors before radiotherapy treatment were investigated. Volume delineation was performed on the CT data and PET/CT data separately. GTV and PTV calculated based on CT and PET/CT images were compared using SPSS software. Results: The GTV increased by 25% or more because of PET in 23.53% of cases. The GTV was reduced >25% in 44.12% of patients. Overall, in 67.65%(23/34) of cases, GTV delineation was changed significantly if information from metabolic imaging was used in the planning process. The modification of the GTV translated into altered PTV changes in 58.52%(20/34) of cases. In 3 cases, 11C-Choline PET/CT revealed distant metastasies, changing the treatment strategy from curative to palliative. In 5 cases, no solid evidence of tumor existence was found and their radiotherapy planning was canceled. Conclusion: Integrated 11C-Choline PET/CT for treatment planning for 3D-CRT improves the accuracy of volume delineation compared with that of CT alone. The impact on treatment outcome remains to be demonstrated.

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brain neoplasms / choline / positron-emission tomography

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HUANG Zhe-min;GUAN Yi-hui;ZHAO Jun;ZUO Chuan-tao;HUA Feng-chun. Application of ¹¹C-Choline PET/CT in radiotherapy planning of brain tumor[J]. Journal of China Clinic Medical Imaging. 2007, 18(11): 781-784