Experimental study on MR perfusion weighted imaging in acute cerebral venous occlusion

GUO Da-jing; KONG Xiang-quan; WANG Zhi-gang; ZHAO Jian-nong; CHEN Wei-juan; XIE Wei-bo

Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (12) : 851-854.

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Experimental study on MR perfusion weighted imaging in acute cerebral venous occlusion

GUO Da-jing1, KONG Xiang-quan2, WANG Zhi-gang1, ZHAO Jian-nong1, CHEN Wei-juan1, XIE Wei-bo1

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Abstract

Objective: To evaluate a model of acute cerebral venous occlusion with MR perfusion weighted imaging(PWI), and to observe the changes of the brain parenchymal lesions. Materials and Methods: Twenty-four cats were randomly divided into 2 groups, including operation group(n=18) and sham operation group(n=6). Craniotomy was performed and the cellulose acetate polymer(CAP) solution was injected into the superior sagittal sinus to prepare a model of acute cerebral venous occlusion in operation group. PWI was continually performed at an interval of 1, 3, 6, 12, 24 and 48h after operation for each group to observe the brain parenchymal lesions, the pathologic changes were compared with MRI data. Results: In operation group, twenty-three abnormal perfusion regions were detected on PWI in 15 cats, appearing as prolonged mean time to enhance(MTE) increased, normal or decreased regional cerebral blood volume(rCBV). Relative MTE(rMTE) of the central and marginal region prolonged slightly in 1, 3, 6h and prolonged obviously in 12h. Relative rCBV(rrCBV) in the central region of lesions decreased obviously in 6h, while rrCBV of marginal region decreased gradually in 12h and obviously in 24h. rrCBV of the central region showed significant difference(t=-4.91, P＜0.05) compared with marginal region in 6h. Pathologic examination mainly showed vasogenic edema in the lesions, followed by necrosis in 12h and sometimes with venous hemorrhagic infarction. No abnormal change was observed in sham operation group. Conclusion: PWI has great value in judging the dynamic changes and the pathogenesis of brain parenchymal lesions in acute cerebral venous occlusion.

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brain diseases / cerebral veins / magnetic resonance imaging

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GUO Da-jing;KONG Xiang-quan;WANG Zhi-gang;ZHAO Jian-nong;CHEN Wei-juan;XIE Wei-bo. Experimental study on MR perfusion weighted imaging in acute cerebral venous occlusion[J]. Journal of China Clinic Medical Imaging. 2007, 18(12): 851-854