Study of 1H-MRS for retroperitoneal neuroblastoma pre- and post-chemotherapy in children

GAO Yu; LIU Ming; ZHANG Yu-zhen; ZHONG Yu-min; ZHANG Yong-ping; LI Yu-hua

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Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (4) : 251-253.

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Study of 1H-MRS for retroperitoneal neuroblastoma pre- and post-chemotherapy in children

GAO Yu, LIU Ming, ZHANG Yu-zhen, ZHONG Yu-min, ZHANG Yong-ping, LI Yu-hua

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Abstract

Objective: To observe the histochemical change of MRS in pre- and post-chemotherapy of retroperitoneal neuroblastoma and predict the resistance or response to chemotherapy by 1H-MRS. Materials and Methods: MRI and MRS were performed in 20 cases pre- and post-chemotherapy. Twelve were boys and 8 were girls, the age ranged from 3 months to 12 years, the mean age was 4.5. The variation of the ratio of mobile lipid and choline pre- and post-chemotherapy were observed. Results: There is a significant difference of the ratio of mobile lipid and choline pre- and post-chemotherapy. Conclusion: The significant change of the ratio of mobile lipid and choline pre- and post-chemotherapy may be as a tool to predict the resistance or response to chemotherapy.

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child / neuroblastoma / magnetic resonance imaging

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GAO Yu;LIU Ming;ZHANG Yu-zhen;ZHONG Yu-min;ZHANG Yong-ping;LI Yu-hua. Study of 1H-MRS for retroperitoneal neuroblastoma pre- and post-chemotherapy in children[J]. Journal of China Clinic Medical Imaging. 2007, 18(4): 251-253