Clinical application of brown algae-microballs particles and gelfoam in partial splenic embolization for hypersplenism in cirrhosis

HE Zhi-ming; XIE Xiao-dong; YANG Huai-long; JI Yan; WANG Hong

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Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (5) : 336-339.

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Clinical application of brown algae-microballs particles and gelfoam in partial splenic embolization for hypersplenism in cirrhosis

HE Zhi-ming1, XIE Xiao-dong2, YANG Huai-long1, JI Yan1, WANG Hong1

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Abstract

Objective: To evaluate the efficacy and complications of partial splenic embolization(PSE) using brown algae microballs and gelfoam as embolic materials for hypersplenism in cirrhosis. Methods: Seventy-four patients with hypersplenism and cirrhosis were treated by PSE and followed up for 1 year. According to the difference of the embolic material in PSE, 60 patients were divided into 2 groups. Group A: 22 patients with gelfoam cubes as the embolic material of PSE and group B: 38 patients with brown algae microballs. The follow-up indices included peripheral blood cell counts(WBC, PLT, RBC) and the complications associated with PSE. Results: In group A and B, WBC and PLT counts kept significantly higher in number than pre-embolization from 2 weeks to 1 year after PSE(P<0.001). Though WBC and PLT counts reached higher level after PSE in group B than that in group A but without significant difference(P>0.05). RBC counts did not show significant changes after PSE within 1 year follow-up(P>0.05). The most frequent side-effects were belly ache and fever. The degree and duration of belly ache were higher and longer in group B than those in group A, but the occurrence rate of fever was lower in group B. The occurrence rate of severe complications showed no significant differences for the two groups. The increase of embolization degree may aggravate post-embolization side-effects and raise the incidence of complications. Conclusion: Brown algae microballs may be more safe than gelfoam as the embolic material for PSE.

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hypersplenism / embolism

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HE Zhi-ming;XIE Xiao-dong;YANG Huai-long;JI Yan;WANG Hong. Clinical application of brown algae-microballs particles and gelfoam in partial splenic embolization for hypersplenism in cirrhosis[J]. Journal of China Clinic Medical Imaging. 2007, 18(5): 336-339