Correlation study between CT perfusion features and tumoral angiogenesis of rabbit bearing VX2 tumor before and after chemoembolization

CHEN Kun-tao; HE Jian-yuan; GUO Rui-zhen

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Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (8) : 591-593.

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Correlation study between CT perfusion features and tumoral angiogenesis of rabbit bearing VX2 tumor before and after chemoembolization

CHEN Kun-tao, HE Jian-yuan, GUO Rui-zhen

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Abstract

Objective:　To investigate the correlation between CT perfusion features and tumoral angiogenesis of rabbit bearing VX2 tumor before and after chemoembolization. Materials and Methods: Sixty New Zealand white rabbits, the rabbits were injected with VX2 tumor piece into the left lobe of the liver. Fourteen days after implantation the 60 rabbits were divided into contrast group(n=30) and chemoembolization group(n=30) randomly. CT perfusion was performed in the two groups. MVD and expressions of VEGF were examined by immunohistochemical techniques. Statistic analysis was made. Results: There were positive correlation between CT perfusion parameters with MVD and expressions of VEGF. CT perfusion parameters, MVD and expressions of VEGF of the chemoembolization group was lower than those of the contrast group. Conclusions: CT perfusion features can reflect tumoral angiogenesis indirectly, and can estimate the effect of chemoembolization.

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liver neoplasms / tomography / X-ray computed / embolization / therapeutic

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CHEN Kun-tao;HE Jian-yuan;GUO Rui-zhen. Correlation study between CT perfusion features and tumoral angiogenesis of rabbit bearing VX2 tumor before and after chemoembolization[J]. Journal of China Clinic Medical Imaging. 2007, 18(8): 591-593