Comparative study with double-phase 99Tcm-MIBI tomographic imaging and mammography in diagnosis of breast lesions

CHEN Zai-jun; LIANG Qing-mo; ZHENG Zi-gui; BAO Zheng; XU Xian-hua; GUI Wen-lai; LUO Mao-xiang

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Journal of China Clinic Medical Imaging ›› 2007, Vol. 18 ›› Issue (9) : 639-642.

论著

Comparative study with double-phase ⁹⁹Tc^m-MIBI tomographic imaging and mammography in diagnosis of breast lesions

CHEN Zai-jun, LIANG Qing-mo, ZHENG Zi-gui, BAO Zheng, XU Xian-hua, GUI Wen-lai, LUO Mao-xiang

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Abstract

Objective: To evaluate the value of double-phase 99Tcm-MIBI tomographic imaging and mammography in diagnosis of breast lesions. Methods: Double-phase 99Tcm-MIBI tomographic imaging and mammography were performed within one week for patients with breast neoplasms. The final diagnosis were verified with histological examination. Result: ①The T/NT ratios of early and delayed imaging were 2.08±2.85 and 1.69±3.05 in benign lesions. There was significant difference(P<0.05). The T/NT ratios of early and delayed imaging were 5.00±4.34 and 6.79±11.94 in malignant tumors, there was no significant difference(P>0.05). ②The sensitivity of double-phase 99Tcm-MIBI tomographic imaging in diagnosis of breast cancer was 97.1%; specificity was 94.8%; accuracy was 95.7%; the positive predictive value was 91.9%, and the negative predictive value was 98.2%. The sensitivity of mammography in diagnosis of breast cancer was 82.9% and specificity 70.7% and accuracy 75.3% and the positive predictive value 63.0% and the negative predictive value 87.2%, the two methods showed significant difference(P<0.05). Conclusion: The double-phase 99Tcm-MIBI tomographic imaging is superior to the mammography in diagnosing breast cancer, double-phase 99Tcm-MIBI tomographic imaging has higher sensitivity and specificity in the diagnosis of breast cancer. It is an effective means in differentiating benign from malignant lesions.

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breast neoplasms / mammography / radionuclide imaging / Technetium Tc 99m sestamibi

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CHEN Zai-jun;LIANG Qing-mo;ZHENG Zi-gui;BAO Zheng;XU Xian-hua;GUI Wen-lai;LUO Mao-xiang. Comparative study with double-phase ⁹⁹Tc^m-MIBI tomographic imaging and mammography in diagnosis of breast lesions[J]. Journal of China Clinic Medical Imaging. 2007, 18(9): 639-642