MRI evaluation on the treatment of acute cerebral infarction of cat with the combination of bFGF and GbE

LIU Huai-jun; HE Dan; WU Shuo-chun; YANG Hua; FENG Ping-yong; YAN Li-qun

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (1) : 1-4.

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MRI evaluation on the treatment of acute cerebral infarction of cat with the combination of bFGF and GbE

LIU Huai-jun1, HE Dan1, WU Shuo-chun2, YANG Hua1, FENG Ping-yong1, YAN Li-qun1

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Abstract

Objective: To evaluate the therapeutic effect of bFGF and GbE on acute cerebral infarction with MR imaging. Methods: Forty healthy adult cats were equally and randomly devided into 4 groups. All animals were operated to establish the feline models of cerebral focal ischemia-reperfusion by left transorbital approach. They were injected with sodium chloride intravenously for group A, bFGF for group B, GbE for group C and bFGF+GbE for group D. MR scans performed after operation, included T1WI, T2WI, FLAIR, DWI. Philips’s criteria score were evaluated on the cats. Result: The neurological defects score in group D is remarkably lower than that in group B and C. The lesion on T1WI, T2WI, FLAIR, DWI showed more milder. The area of infarct formation were smaller than that in group B and C through the comparison between the ADC images and T2WI images(T2WI-ADC). Conclusion: The treatment results in group D was better than that in group B and C. Both bFGF and GbE can enhance each other’s therapeutic effects. MR imaging could show the therapeutic effect of bFGF and GbE, especially the T2WI-ADC was an important item to evaluate the therapeutic effects.

Key words

Fibroblast growth factor 2 / Ginko biloba / Brain infarction / Animal experimentation / Cats / Magnetic resonance imaging

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LIU Huai-jun;HE Dan;WU Shuo-chun;YANG Hua;FENG Ping-yong;YAN Li-qun. MRI evaluation on the treatment of acute cerebral infarction of cat with the combination of bFGF and GbE[J]. Journal of China Clinic Medical Imaging. 2008, 19(1): 1-4