Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas

ZHANG Yi-nian; HE Ning; ZHOU Jun-lin

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (1) : 10-14.

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Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas

ZHANG Yi-nian, HE Ning, ZHOU Jun-lin

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Abstract

Objective: To investigate the correlation between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer(EMMPRIN) and Galectin-3 in pituitary adenomas. Methods: MRI was performed preoperatively in 34 patients with histologically verified pituitary adenomas, EMMPRIN and Galectin-3 expression were determined by immunohistochemical SP method in all patients. The correlation between expression of determined proteins and MRI features between invasive and non-invasive pituitary adenomas were studied. Results: Among MRI invasive features, Knosp score, Cottier score, irregular tumor shape and bilateral intracavernous carotid artery asymmetry correlated with increased expression of EMMPRIN and Galectin-3(P<0.05). Conclusion: MRI features of cavernous sinus invasion may be related to the expression of EMMPRIN and Galectin-3, MRI is very useful in diagnosing invasive extent of cavernous sinus in pituitary adenomas.

Key words

Pituitary neoplasms / Adenoma / Matrix metalloproteinases / Galectin 3 / Magnetic resonance imaging

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ZHANG Yi-nian;HE Ning;ZHOU Jun-lin. Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas[J]. Journal of China Clinic Medical Imaging. 2008, 19(1): 10-14