Comparison of combination specification of the different tumor cell with RGD peptide

JIA Ying-ying; QIAN Hai-li; TANG Meng; ZHAO Zhou-she; LI Hong-li; XIN Jun; ZHANG Li-sheng; LIN Chen

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (1) : 35-37.

论著

Comparison of combination specification of the different tumor cell with RGD peptide

JIA Ying-ying1, QIAN Hai-li2, TANG Meng1, ZHAO Zhou-she3, LI Hong-li3, XIN Jun4, ZHANG Li-sheng5, LIN Chen2

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Abstract

Objective: To get the αvβ3 receptor combination information of the different tumor cells with RGD peptide by vivo and vitro method, so as to guide clinical molecular imaging research. Materials and Methods: Comparison combination specification of the pancreas tumor cell, hepatic tumor cell, intestine tumor cell and cervix tumor cell with FITC-HYNIC-RGD, and acquisition data for the xenograft mice model of breast tumor and hepatic tumor cell after IV injection of 99mTc-HYNIC-RGD. Results: Combination number of the pancreas tumor cell, hepatic tumor cell is higher than intestine tumor cell and cervix tumor cell with FITC-HYNIC-RGD. The uptake of breast tumor cell with 99mTc-HYNIC-RGD is 40% higher than that of hepatic tumor cell after injection. Conclusion: Combination of the pancreas tumor cell, hepatic tumor cell with FITC-HYNIC-RGD is the highest. Uptake of breast tumor with xenograft mice model is higher than hepatic tumor after injection of 99mTc-HYNIC-RGD.

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Neoplasms / Peptides / Isotope labeling

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JIA Ying-ying;QIAN Hai-li;TANG Meng;ZHAO Zhou-she;LI Hong-li;XIN Jun;ZHANG Li-sheng;LIN Chen. Comparison of combination specification of the different tumor cell with RGD peptide[J]. Journal of China Clinic Medical Imaging. 2008, 19(1): 35-37