Correlation of CT value on contrast-enhanced CT, MVD and the expression of VEGF in renal pelvic carcinoma and its clinical significance

ZHANG Xiu-li; LIU Ling; WANG Zhao-hui; LV Shen; LI Mei

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (10) : 711-714.

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Correlation of CT value on contrast-enhanced CT, MVD and the expression of VEGF in renal pelvic carcinoma and its clinical significance

ZHANG Xiu-li, LIU Ling, WANG Zhao-hui, LV Shen, LI Mei

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Abstract

To investigate the correlation of CT value on contrast-enhanced CT, MVD and VEGF expression in renal pelvic carcinoma and to explore its clinical significance. Methods: The expression of VEGF and CD34 was evaluated by immunohistochemistry and the MVD was counted in 26 cases of renal pelvic carcinoma. CT value on enhanced CT were measured and divided into three groups of CT enhancement, slight, moderate and obvious enhancement. The correlation of CT value, VEGF and MVD was calculated statistically and the relationship between them and clinical stages of the tumor were also analyzed. Results: There was significant difference of MVD in the three different CT enhancement groups. There was no statistical correlation between CT enhancement and VEGF expression; There was no significant correlation between CT enhancement and clinical stages. There was positive correlation between expression of VEGF and clinical stages. There was no significant difference of MVD among different clinical stages and different groups of VEGF expressions. Conclusion: The CT enhancement of the tumor can properly reflect the tumor’s blood supply and neovascularization, and was correlated with tumor’s MVD. The expression of VEGF increased with the clinical stages. But MVD did not increase with the increasing expression of VEGF and clinical stages. The CT enhancement of the tumor did not increase with the clinical stages either, which may be due to the vascular permeability effect of VEGF.

Key words

Kidney neoplasms / Tomography / spiral computed

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ZHANG Xiu-li;LIU Ling;WANG Zhao-hui;LV Shen;LI Mei. Correlation of CT value on contrast-enhanced CT, MVD and the expression of VEGF in renal pelvic carcinoma and its clinical significance[J]. Journal of China Clinic Medical Imaging. 2008, 19(10): 711-714