Hepatocellular carcinoma: a correlative study between its blood supply types on multislice spiral CT and HIF-1α expression

XIE Yun-chuan; ZHOU Xiang-ping

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (5) : 326-329.

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Hepatocellular carcinoma: a correlative study between its blood supply types on multislice spiral CT and HIF-1α expression

XIE Yun-chuan, ZHOU Xiang-ping

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Abstract

Objective: To study the correlation between blood supply types on multislice spiral CT and hypoxia inducible factor-1α(HIF-1α) expression in hepatocellular carcinoma(HCC). Methods: In 34 cases HCC identified with operation and pathology, the relationship between blood supply types on multislice spiral CT during dual-phase scanning and the expression levels of HIF-1α and vascular endothelial growth factor(VEGF) in HCC with immunohistochemistry staining in SP and Edmondson-Steiner grading. Results: Among the four blood supply types, both the strong positive staining and the positive staining are the highest in the arterial blood supply type, followed by the arterial combining with portal blood supply type. The two lowest types are portal blood supply type and poorly blood supply type(P<0.001). With the increasing of the Edmondson-Steiner histological grades, the expression of HIF-1α levels also increase correspondingly(P<0.05). Conclusion: The blood supply type of HCC and the HIF-1α expression levels that reflects the HCC angiogenesis condition and the histological grades can be judged to some extent by using multislice spiral CT during dual-phase scanning. Hence it will be useful for the selecting of HCC treatment plans including anti-angiogenesis and evaluating the prognosis.

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Liver neoplasms / Tomography / X-ray computed

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XIE Yun-chuan;ZHOU Xiang-ping. Hepatocellular carcinoma: a correlative study between its blood supply types on multislice spiral CT and HIF-1α expression[J]. Journal of China Clinic Medical Imaging. 2008, 19(5): 326-329