Comparison of establishing rabbit model bearing VX2 tumor in two methods and its meaning for interventional therapy

SI Guang-yan; ZHOU Shi; WANG Xue-jian; ZHANG Wei; GUO Jian-xing; JIANG Tian-peng

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (6) : 391-394.

论著

Comparison of establishing rabbit model bearing VX2 tumor in two methods and its meaning for interventional therapy

SI Guang-yan1, ZHOU Shi2, WANG Xue-jian2, ZHANG Wei2, GUO Jian-xing2, JIANG Tian-peng2

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Abstract

Objective: To compare the difference of two methods of establishing rabbit model bearing VX2 liver tumor and explore its meaning for trans-catheter arterial chemoembolization and percutaneous ablation therapy. Method: Forty Japanese white rabbits were divided into two groups randomly, 20 in each group. VX2 tumor pieces mixed with sodium chloride were injected into the liver by laparotomic route in group A and VX2 tumor pieces were implanted under the hepatic capsule in group B. The observation included: ①the liver and abdominal cavity by color Doppler ultrasound after two weeks. ②The growth of tumor in liver and metastasis in the abdominal cavity after killing the rabbits. ③Identify the tumor tissue by HE staining. Differences of the two groups were statistically assessed with χ2 tests. Result: The mean period of surgery and bleeding were not significant in the two groups. The rabbits with liver neoplasms in group A was 11 cases and group B was 19 cases seen by color Doppler ultrasound. The discovery rate of liver mass in group B was higher than in group A(P＜0.05). Having liver neoplasms only in the transplanted site of group A was 10 cases and group B was 16 cases. Group B was higher than group A(P＜0.05). The cases of successful transplanted carcinoma in group A was 17 and in group B was 19. There were no statistically difference between the two groups(P＞0.05). Conclusion: The successful rate of transplanted carcinoma had no significant difference between embedding and injecting method through abdominal incision, but ectopia implantation in the former is few, it suits empirical study of trans-catheter arterial chemoembolization and percutaneous ablation therapy.

Key words

Liver neoplasms / experimental / Embolization / therapeutic / Catheter ablation / Rabbits

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SI Guang-yan;ZHOU Shi;WANG Xue-jian;ZHANG Wei;GUO Jian-xing;JIANG Tian-peng. Comparison of establishing rabbit model bearing VX2 tumor in two methods and its meaning for interventional therapy[J]. Journal of China Clinic Medical Imaging. 2008, 19(6): 391-394