An experimental study of CT perfusion imaging in revealing the correlation ofcerebral blood volume, permeability and the VEGF expression

GUAN Li-ming; XU Ke; QI Xi-xun; FANG Chang-xing; LIU Shu-li

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (8) : 547-550.

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An experimental study of CT perfusion imaging in revealing the correlation ofcerebral blood volume, permeability and the VEGF expression

GUAN Li-ming, XU Ke, QI Xi-xun, FANG Chang-xing, LIU Shu-li

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Abstract

Objective: To evaluate cerebral blood volume(CBV) and permeability surface(PS) of rat C6 brain gliomas by CT perfusion and to study the correlation with VEGF expression. Methods: C6 cells were inoculated into the right caudate nucleus of 30 Wistar rats by stereotactic procedure to establish animal model. CT perfusion was performed on 1 week, 2 and 3 weeks after implantation. Immediately after each examination, some rats were sacrificed for pathology. Results: All CBV and PS values of the tumors at 1 week, 2 and 3 weeks after implantation increased compared to those of the contralateral sides(P<0.05). The PS value in the center of the tumor at 2 and 3 weeks after implantation were larger than that in the peripheral regions of the tumors(P<0.01). The PS value had statistical difference comparing with that of the tumors at 1 week and central tumoral regions both at 2 and 3 weeks after implantation(P<0.05). Expression of VEGF was observed adjacent to the vessel especially at the periphery of the tumors and increased gradually, positive correlation was present not only between central-tumor CBV and PS(rs=0.453, P<0.05) but also at both peripheral-tumor CBV and PS(rs=0.443 and 0.742 respectively, P<0.05) and VEGF expression under the development of the tumors. Conclusion: The blood volume and permeability of different tumor regions increase with the development of rat C6 brain gliomas, and perhaps there is a close correlation between both CBV and PS values and expression of VEGF.

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Brain neoplasms / Glioma / Tomography / X-ray computed

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GUAN Li-ming;XU Ke;QI Xi-xun;FANG Chang-xing;LIU Shu-li. An experimental study of CT perfusion imaging in revealing the correlation ofcerebral blood volume, permeability and the VEGF expression[J]. Journal of China Clinic Medical Imaging. 2008, 19(8): 547-550