Effect of transcatheter uterine arterial chemoembolization on VEGF, MVD of cervical carcinoma

ZHANG Guo-ling; ZHAO Xin-jian; GAO Yong-chang

Journal of China Clinic Medical Imaging ›› 2008, Vol. 19 ›› Issue (9) : 646-648.

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Effect of transcatheter uterine arterial chemoembolization on VEGF, MVD of cervical carcinoma

ZHANG Guo-ling, ZHAO Xin-jian, GAO Yong-chang

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Abstract

Objective: To evaluate the influence of transcatheter uterine arterial chemoembolization on expression of vascular endothelial growth factor(VEGF) and micro vascular density(MVD) of cervical cancer. Methods: Immunohistochemical exam was performed to detect the expression of VEGF and MVD in 42 cases of cervical carcinoma before and after transcatheter uterine arterial chemoembolization. Results: After transcatheter uterine arterial chemoembolization, the expression of VEGF decreased from 67％(28/42) to 35％(15/42), while MVD also decreased remarkably(P<0．05). Conclusions: Transcatheter uterine arterial chemoembolization can decrease expression of VEGF and MVD and may able to suppress the growth and metastasis of cervical cancer.

Key words

Cervix neoplasms / Vascular endothelial growth factor A / Embolization / therapeutic

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ZHANG Guo-ling;ZHAO Xin-jian;GAO Yong-chang. Effect of transcatheter uterine arterial chemoembolization on VEGF, MVD of cervical carcinoma[J]. Journal of China Clinic Medical Imaging. 2008, 19(9): 646-648