An fMRI study for different cognition components of working memory in schizophrenia patients

YANG Gui-fen; ZHANG Quan; ZHANG Yun-ting; SHEN Jian-hua; ZHANG Xin-jun; CHEN Qing-gang

Journal of China Clinic Medical Imaging ›› 2009, Vol. 20 ›› Issue (10) : 758-761.

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An fMRI study for different cognition components of working memory in schizophrenia patients

YANG Gui-fen1, ZHANG Quan2, ZHANG Yun-ting2, SHEN Jian-hua3, ZHANG Xin-jun3, CHEN Qing-gang3

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Abstract

Objective: To investigate the difference of neural mechanism for different cognition components with encoding, maintenance and retrieval process of working memory(WM) between schizophrenia patients and normal subjects using event-related fMRI(ER-fMRI). Methods: Sixteen normal subjects and twenty schizophrenia subjects completed a Sternberg item recognition task using fMRI. Brain activation regions for encoding, maintenance and retrieval process were obtained. Result: Compared to normal subjects, some functional regions associated with encoding, maintenance and retrieval process showed increased activation in schizophrenia patients, i.e. right precuneus for encoding process, left PMA, left DLPFC, right precuneus and left VLPFC for maintaince process, left PMA for retrieval process. In addition, subcortical structures, primary motor cortex and some verbal regions in left temporal lobe also showed more activation. Conclusion: Some functional regions associated with encoding, maintenance and retrieval process showed relatively inefficiency in schizophrenia patients.

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Schizophrenia / Magnetic resonance imaging

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YANG Gui-fen;ZHANG Quan;ZHANG Yun-ting;SHEN Jian-hua;ZHANG Xin-jun;CHEN Qing-gang. An fMRI study for different cognition components of working memory in schizophrenia patients[J]. Journal of China Clinic Medical Imaging. 2009, 20(10): 758-761