Preliminary study of PWI in rabbit models of hepatic VX2 tumors after high intensity focused ultrasound

CHEN Liang; JIANG Xin-qing; WEI Xin-hua; XIA Jian-dong; WU Mei; WU Hong-zhen; ZHENG Li-qiang

Journal of China Clinic Medical Imaging ›› 2009, Vol. 20 ›› Issue (3) : 174-177.

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Preliminary study of PWI in rabbit models of hepatic VX2 tumors after high intensity focused ultrasound

CHEN Liang, JIANG Xin-qing, WEI Xin-hua, XIA Jian-dong, WU Mei, WU Hong-zhen, ZHENG Li-qiang

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Abstract

Objective: To discuss the basic characteristic of perfusion-weighted imaging(PWI) in rabbit models of hepatic VX2 tumors after treatment by high intensity focused ultrasound(HIFU). Methods: VX2 tumor in tissue block were implanted into the liver of 20 new Zealand rabbits to make VX2 liver tumor model. After routine scans with 1.5T MR scanner, PWI was performed in 14 days before and after tumor implantation in all animals by using EPI-SE series and SENSE technology. Choose the ROI of rabbit liver VX2 such as central district, marginal area and paratumor parenchyma. Blood flow degrees were measured and analyzed statistically. Maximal signal reduction slope(SRSmax) of the signal intensity versus time curves were created as quantitative variable. Analyze the change of SRSmax in different ROI. Results: There were difference in SRSmax between the central district and the marginal area(P<0.05). No difference in SRSmax in paratumor parenchyma before and after HIFU(P>0.05). Conclusion: It is feasible to study VX2 of rabbit liver perfusion imaging by 1.5T MRI scanner. PWI can be used to evaluate the situation of the liver tumor angiogenesis and angioruin. The findings of VX2 carcinomas on PWI are matched with the levels and scopes of necrosis.

Key words

Liver neoplasms / Models / animal / Ultrasonography / Magnetic resonance imaging

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CHEN Liang;JIANG Xin-qing;WEI Xin-hua;XIA Jian-dong;WU Mei;WU Hong-zhen;ZHENG Li-qiang. Preliminary study of PWI in rabbit models of hepatic VX2 tumors after high intensity focused ultrasound[J]. Journal of China Clinic Medical Imaging. 2009, 20(3): 174-177