Comparison of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy in detection of bone metastasesof lung cancer

XU Wei-na; XIN Jun; YU Shu-peng; WANG Xiao-ming; GUO Qi-yong

Journal of China Clinic Medical Imaging ›› 2009, Vol. 20 ›› Issue (5) : 323-326.

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Comparison of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy in detection of bone metastasesof lung cancer

XU Wei-na, XIN Jun, YU Shu-peng, WANG Xiao-ming, GUO Qi-yong

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Abstract

Objective: To compare the diagnostic value of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy for the detection of bone metastases in patients with lung cancer. Methods: We examined 49 patients, 28 men, 21 women with lung cancer, mean age (58.9±10.8)years. All patients underwent both whole-body 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy within 10 days. Bone metastases were verified either by pathological results or MR findings or follow-up more than half a year. Results: Bone metastases were confirmed in 228 of the 259 foci. The sensitivity for bone metastases using 18F-FDG PET-CT and 99mTc-MDP as 90.8% and 56.6% respectively, the specificity was 93.5% and 45.2% respectively. The accuracy was 91.1% and 55.2% respectively. Conclusion: The specificity and the overall accuracy of 18F-FDG PET-CT for the diagnosis of bone metastases in patients with lung cancer are higher than those of 99mTc-MDP bone scintigraphy.

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Lung neoplasms / Neoplasm metastasis / Bone neoplasms / Positron-emission tomography / Tomography / emission-computed / single-photon

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XU Wei-na;XIN Jun;YU Shu-peng;WANG Xiao-ming;GUO Qi-yong. Comparison of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy in detection of bone metastasesof lung cancer[J]. Journal of China Clinic Medical Imaging. 2009, 20(5): 323-326