The technology of first-pass perfusion MR imaging and delayed enhanced MR imaging in the swine myocardial infarction model: a preliminary study

YANG Xin-huan; ZHAO Xin-xiang; YAN Dong; YUAN Shu-guang

Journal of China Clinic Medical Imaging ›› 2010, Vol. 21 ›› Issue (10) : 697-700.

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The technology of first-pass perfusion MR imaging and delayed enhanced MR imaging in the swine myocardial infarction model: a preliminary study

YANG Xin-huan, ZHAO Xin-xiang, YAN Dong, YUAN Shu-guang

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Abstract

Objective: To investigate the dose of first-pass perfusion and the best delayed scanning time. Thereby, the purpose is to get a better cardiac perfusion MRI images and the best delay-enhanced images. Method: Five experimental pigs with myocardial infarction underwent two MR myocardial first-pass perfusion imaging, the contrast agent dose were 0.05mmol/kg and 0.1mmol/kg respectively. Ten experimental pigs with myocardial infarction underwent delayed enhanced MR imaging at 5min, 10min, 30min, 40min time point. The results were analyzed statistically. Result: There was statistical difference(P<0.05) between the two groups(0.05mmol/kg and 0.1mmol/kg) in detection of the myocardial perfusion decrease or defect on the first-pass MR perfusion imaging. The data of the delayed enhancement MR imaging in different scanning time showed. ①The signal values were statistically significant between 10 minutes and 5 minutes, 40 minutes and 30 minutes; ②The signal values of myocardial infarction showed rise in the stage of 5～10 minutes; and the signal values were relatively stable in the 10～30 minutes; During the stage of 30～40 minutes, the signal value of myocardial infarction showed a clear downward trend compared with the previous time. Conclusion: The perfusion imaging quality of the dose of the 0.1mmol/kg group is better than the 0.05mmol/kg group. It can detect more myocardial perfusion defects. Delayed time between 10～30min is the best scanning time to the delayed enhancement MR imaging. These are helpful in the assessment of myocardial viability using MR first-pass myocardial perfusion imaging and delayed enhancement MR imaging.

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Myocardial infarction / Animal experimentation / Swine / Magnetic resonance imaging

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YANG Xin-huan;ZHAO Xin-xiang;YAN Dong;YUAN Shu-guang. The technology of first-pass perfusion MR imaging and delayed enhanced MR imaging in the swine myocardial infarction model: a preliminary study[J]. Journal of China Clinic Medical Imaging. 2010, 21(10): 697-700