18F-FDG PET/CT imaging in the diagnosis of postoperative of gastric cancer recurrence and metastasis

BAO Jun-chu; ZHOU Wen-lan; WANG Quan-shi; LI Cong-hai; HUANG Ying-he

Journal of China Clinic Medical Imaging ›› 2010, Vol. 21 ›› Issue (10) : 701-704.

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18F-FDG PET/CT imaging in the diagnosis of postoperative of gastric cancer recurrence and metastasis

BAO Jun-chu1, ZHOU Wen-lan2, WANG Quan-shi2, LI Cong-hai1, HUANG Ying-he1

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Abstract

Objective: To assess the value of 18F-fluorodeoxyglucose positron emission and computed tomography(18F-FDG PET/CT) in the post-operative patients with gastric cancer recurrence and metastasis. Methods: Of all the 112 patients who had received PET/CT examination for 150 times, the image analysis using visual and semi-quantitative analysis(SUVave), lesions confirmed according to the results of pathological examination, a variety of imaging techniques and clinical follow-up examination, follow-up time for more than half a year. Results: Sixteen cases showed tumor recurrence and metastasis, PET/CT diagnosis of gastric remnant recurrence sensitivity was 81.2%, specificity was 100%, accuracy was 97.3%. SUVave of recurrent lesions was 4.4±1.2, SUVave of anastomotic inflammatory lesions was 2.6±0.5, difference was statistically significant(t=3.9370, P=0.0005). PET/CT diagnosis of gastric cancer metastasis: sensitivity was 94.1%, specificity was 96.7% and accuracy was 95.5%. Twenty-six cases who had received PET/CT examination for two or more than two times, 15 cases who received the first PET/CT examination and 6 cases showed improvement after radiotherapy and chemotherapy. These patients survived after 6 months to 2 years of follow-up; PET imaging in 9 cases after treatment showed no significant change in conditions or the emergence of new lesions, the patient survival time was 3 months to 1 year. Conclusions: 18F-FDG PET/CT in the postoperative recurrence and metastasis of gastric cancer have a good diagnostic value, and have certain value in monitoring postoperative chemotherapy of gastric cancer.

Key words

Stomach neoplasms / Recurrence / Neoplasms metastasis / Positron-emission tomography / Tomography / X-ray computed

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BAO Jun-chu;ZHOU Wen-lan;WANG Quan-shi;LI Cong-hai;HUANG Ying-he. 18F-FDG PET/CT imaging in the diagnosis of postoperative of gastric cancer recurrence and metastasis[J]. Journal of China Clinic Medical Imaging. 2010, 21(10): 701-704