The imaging characteristics of hereditary spastic paraplegia with thin corpus callosum

LI Xiao-dong; GAO Pei-hong; WANG Gui-bin; CHE Feng-yuan; WANG Jin-liang; GAO Nai-yong; WANG Gui-ling

Journal of China Clinic Medical Imaging ›› 2010, Vol. 21 ›› Issue (7) : 465-468.

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The imaging characteristics of hereditary spastic paraplegia with thin corpus callosum

LI Xiao-dong1, GAO Pei-hong2, WANG Gui-bin2, CHE Feng-yuan2, WANG Jin-liang2, GAO Nai-yong2, WANG Gui-ling2

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Abstract

Objective: To analyze the imaging characteristics of hereditary spastic paraplegia with thin corpus callosum(HSP-TCC), so as to get a better understanding of the disease. Methods: Three patients from the same family with HSP-TCC were reported with reviewing of the literature. Results: Thin corpus callosum, long T2 signal in the thinning cervical and thoracic spinal cord were seen. Diffused unspecific white matter lesions with mild brain atrophy, were also seen in the three HSP-TCC cases of this group. Conclusion: The central nervous system may be affected extensively by HSP-TCC, characteristic MRI signs including thin corpus callosum, long T2 signal in the white matter around lateral ventricle and in the spinal cord, atrophy and abnormal signal of the spinal cord, as well as subsequent mild or moderate brain atrophy.

Key words

Spastic paraplegia / hereditary / Corpus callosum / Magnetic resonance imaging

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LI Xiao-dong;GAO Pei-hong;WANG Gui-bin;CHE Feng-yuan;WANG Jin-liang;GAO Nai-yong;WANG Gui-ling. The imaging characteristics of hereditary spastic paraplegia with thin corpus callosum[J]. Journal of China Clinic Medical Imaging. 2010, 21(7): 465-468