Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits

YANG Xin; WANG Wei; CAO Xia; ZHENG Chun-mei; MA Chun-yan; REN Wei-dong

Journal of China Clinic Medical Imaging ›› 2010, Vol. 21 ›› Issue (8) : 547-548.

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Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits

YANG Xin1, WANG Wei1, CAO Xia1, ZHENG Chun-mei1, MA Chun-yan2, REN Wei-dong2

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Abstract

Objective: To assess the effect of simvastatin on vascular endothelial function by high frequency sonography. Methods: Fifty rabbits were randomly divided into control group(A group) and atherosclerotic group(B group) and simvastatin group(C group). Endothelial dependent dilation(EDD) and non-endothelial dependent dilation(NEDD) were measured with high resolution sonography at different time. Results: After intervention of simvastatin, the blood lipid decreased, EDD function was obviously improved, and NEDD was improved after 12 weeks. There was significant difference between the two groups. Conclusions: Simvastatin can improve endothelial function. High frequency sonography can be used to assess the effect of drug therapy on endothelial function.

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Arteriosclerosis / Endothelium vascular / Ultrasonography

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YANG Xin;WANG Wei;CAO Xia;ZHENG Chun-mei;MA Chun-yan;REN Wei-dong. Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits[J]. Journal of China Clinic Medical Imaging. 2010, 21(8): 547-548