Response of osteosarcoma to chemotherapy evaluated by 18F-FDG imaging

FENG Jin; PENG Jing-jing; LIU Hong-hong; YANG Fang; NIU Xiao-hui

Journal of China Clinic Medical Imaging ›› 2010, Vol. 21 ›› Issue (9) : 638-641.

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Response of osteosarcoma to chemotherapy evaluated by 18F-FDG imaging

FENG Jin, PENG Jing-jing, LIU Hong-hong, YANG Fang, NIU Xiao-hui

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Abstract

Objective: To evaluate potential role of 18F-fluoro-2-deoxy-D-glucose(18F-FDG) in assessing chemotherapy response of primary osteosarcoma. Methods: Seven patients with osteosarcoma confirmed by pathology were examined with 18F-FDG imaging before and after chemotherapy. Two practiced nuclear medicine doctor observed the image and do the semi-quantitative analysis. Tumor to non-tumor radioactivity count ratios(TNR) was used. The radioactivity count variance ratio before and after chemotherapy obtained by using formula(TNR1-TNR2)/TNR1. The histopathological tumor necrosis were obtained by surgery. Result: The radioactivity count before and after chemotherapy(TNR1max and TNR2max；TNR1average and TNR2average) had significant difference(P<0.05). Four of the 7 patients got histopathological tumor necrosis, which had a significant correlation to the radioactivity count variance ratio. The correlation coefficient of (TNR1-TNR2)/TNR1max and (TNR1-TNR2)/TNR1average with the tumor necrosis were 0.94 and 0.84 respectively. Conclusion: 18F-FDG imaging can be used to assess the chemotherapy response of osteosarcoma noninvasively.The semi-quantitative analysis which has consistency with the histopathological tumor necrosis is helpful in evaluating response of osteosarcoma to chemotherapy.

Key words

Osteosarcoma / Tomography / emission-computed / single-photon / Drug therapy

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FENG Jin;PENG Jing-jing;LIU Hong-hong;YANG Fang;NIU Xiao-hui. Response of osteosarcoma to chemotherapy evaluated by 18F-FDG imaging[J]. Journal of China Clinic Medical Imaging. 2010, 21(9): 638-641