MRI evaluation of bone marrow mesenchymal stem cells in the treatment of cartilage damage in RA rabbit model

ZHOU Zhong-heng; CUI Yan-an; LIU Zhao; LIU Hong-xia; HUANG Hai-qing; ZHANG Quan-bin

Journal of China Clinic Medical Imaging ›› 2011, Vol. 22 ›› Issue (7) : 479-482.

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MRI evaluation of bone marrow mesenchymal stem cells in the treatment of cartilage damage in RA rabbit model

ZHOU Zhong-heng1, CUI Yan-an1, LIU Zhao1, LIU Hong-xia1, HUANG Hai-qing1, ZHANG Quan-bin2

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Abstract

Objective: To observe the effects of bone marrow stem cells(BMSCs) transplantation in treating rheumatoid arthritis(RA) in rabbits by measuring the thickness of knee joint articular cartilage using MRI. Methods: Ovalbumin was used to induce right knee rheumatoid arthritis in 42 New Zealand white rabbits. Four wks later, MRI and pathologic examination were carried out in 6 rabbits, the remaining 36 rabbits were randomly and equally divided into the RA group as control and the BMSCs transplantation group. Normal saline was injected into the right knee joint of the former group and same volume of BMSCs was injected into the right knee joint of the latter group. At 1, 2, 3 months after injection, 6 rabbits at each time point of both groups were given MRI and pathologic examination respectively, the thickness of knee articular cartilage was measured by MRI and the pathologic changes were observed and scorings were recorded. Results: After 1, 2, 3 months the cartilage in the RA group showed thinning and damaged with high pathologic score. While the cartilage was thickened with lower pathologic scorings in the BMSCs group. MRI measurements and pathology scoring correlated well. Conclusion: MRI can be used to evaluate the effect of BMSCs in the treatment of cartilage in early RA.

Key words

Mesenchymal stem cells / Arthritis / rheumatoid / Rabbits / Magnetic resonance imaging

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ZHOU Zhong-heng;CUI Yan-an;LIU Zhao;LIU Hong-xia;HUANG Hai-qing;ZHANG Quan-bin. MRI evaluation of bone marrow mesenchymal stem cells in the treatment of cartilage damage in RA rabbit model[J]. Journal of China Clinic Medical Imaging. 2011, 22(7): 479-482