Perfusion-weighted imaging in hypertensive encephalopathy: animal model study

GAO Bo; LV Cui; LIU Feng-li; YU Guo-hua; BA Mao-wen

Journal of China Clinic Medical Imaging ›› 2012, Vol. 23 ›› Issue (10) : 685-687.

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Perfusion-weighted imaging in hypertensive encephalopathy: animal model study

GAO Bo1, LV Cui2, LIU Feng-li1, YU Guo-hua1, BA Mao-wen1

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Abstract

Objective: To investigate the dynamic changes of hypertensive encephalopathy in animal models by perfusion-weighted imaging(PWI). Methods: Twenty adult New Zealand white rabbits were randomly divided into control group(group A) and study group(group B), 10 cases in each group. A modified Gloidblatt 2K1C were used in rabbits to establish chronic hypertension model for control group, and intramuscular injection of Metaraminol Bitartrate to induce acute hypertension in the study group. Routine MRI scanning and PWI of brain were performed in rabbit models on the 3.0T MRI scanner. The values of CBV, CBF and MTT were calculated in selected region of interest(ROI) at workstation, and were compared among anterior, middle and posterior brain regions. Results: The changes of CBF were most marked in posterior brain regions. The CBV, CBF increased after injection of Metaraminol Bitartrate and reached the peak on the ninth day, later than MAP which reached the peak on the sixth day, and then decreased to a basically normal level after drug withdrawal for one week. The change of MTT was not significant. Conclusions: During the course of hypertensive encephalopathy, the level of rCBF first increases and then declines, the peak of which is later than those of MAP.

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Hypertensive encephalopathy / Models / animal / Magnetic resonance imaging

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GAO Bo;LV Cui;LIU Feng-li;YU Guo-hua;BA Mao-wen. Perfusion-weighted imaging in hypertensive encephalopathy: animal model study[J]. Journal of China Clinic Medical Imaging. 2012, 23(10): 685-687