The value of CE-MRC using Gd-EOB-DTPA in patients with liver cirrhosis

JIN La-mei; WU Jian-wei; QU Xian-li; GAO Hong; ZHANG Yan; LU Guang-ming

Journal of China Clinic Medical Imaging ›› 2013, Vol. 24 ›› Issue (10) : 701-705.

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The value of CE-MRC using Gd-EOB-DTPA in patients with liver cirrhosis

JIN La-mei1, WU Jian-wei1, QU Xian-li1, GAO Hong1, ZHANG Yan1, LU Guang-ming2

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Abstract

Objective: To discuss the value of contrast-enhanced magnetic resonance cholangiography(CE-MRC) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA) in patients with liver cirrhosis. Methods: The dynamic scan and CE-MRC in hepatobiliary phase were performed in 53 patients with liver cirrhosis and 18 normal adults, the image quality of CE-MRC at 5, 10, 15, 20 and 25 minutes in hepatobiliary phase were evaluated, the relationship between signal intensity of common bile ducts and serum total bilirubin level, albumin level and prothrombim time were analyzed. The differences between CE-MRC and MRCP were compared. Results: CE-MRC allowed the visualization of most parts of biliary duct at 15 minutes after administration of Gd-EOB-DTPA in normal adults. The visualization of biliary ducts were delayed in patients with liver cirrohsis, especially in cases with Child-Pugh B and C. There were no differences of signal intensity of common bile ducts at 25 minutes delayed between the normal adults and patients with Child-Pugh A(P=0.570), while there were differences between normal adults and Child-Pugh B(P=0.002), between Child-Pugh A and Child-Pugh B(P=0.000). In patients with liver cirrhosis, the correlation coefficient between signal intensity of common bile ducts and prothrombin time was -0.57, CE-MRC and MRCP showed 79% and 32% of the cystic ducts respectively(χ2=23.891, P=0.000) and had the similar ability for displaying the second order division ducts, bilateral hepatic ducts and common bile ducts(P＞0.05). Conclusion: It was suitable that CE-MRC were performed at 25 minutes after contrast administration in patients with liver cirrhosis. The liver funcion affected the time of visualization and signal intensity of bile ducts, CE-MRC had the advantage for detecting the cystic ducts than MRCP. CE-MRC combined with MRCP allowed evaluation for structure and function of biliary system effectively.

Key words

Liver cirrhosis / Cholangiopancreatography / magnetic resonance

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JIN La-mei;WU Jian-wei;QU Xian-li;GAO Hong;ZHANG Yan;LU Guang-ming. The value of CE-MRC using Gd-EOB-DTPA in patients with liver cirrhosis[J]. Journal of China Clinic Medical Imaging. 2013, 24(10): 701-705