Abstract
Objective: To compare the difference of T2* value in several cerebral regions between idiopathic Parkinson’s disease(PD) patients and control subjects and to quantitatively analyze the variations of brain iron． Methods: Twenty-four patients with idiopathic PD and 24 healthy controls, ranging in same ages and gender, had routine sequences and SWI sequences by 3.0T MR. T2* value was measured in both sides of substantia nigra pars compacta(SNc), substantia nigra pars reticulata(SNr), red nucleus(RN), globus pallidus(GP), putamen(PUT), head of caudate nucleus(CN), thalamus(THA) and frontal white matter(FWM), and statistically analyzed． Results: ①The T2* values was reduced in homolateral side SNc of symptoms of subjects with idiopathic PD compared with the contralateral side(P<0.05). There were no differences in other regions(P＞0.05). ②The T2* values was reduced in contralateral side SNc and SNr of symptomatic subjects with idiopathic PD compared with the homolateral side(P<0.05). There were no significant difference in other regions(P＞0.05). ③There was a significant reduction in the T2* values in contralateral side SNc and RN of symptomatic subjects with idiopathic PD compared with the contralateral side(P<0.05). There were no differences in other regions(P＞0.05). ④No significant difference was demonstrated in T2* values in all regions in homolateral side of symptomatic subjects with idiopathic PD compared with the contralateral side(P＞0.05). There was no significant difference in the T2* values between the two sides in the idiopathic PD group, the two sides in the subjects group(P＞0.05)． Conclusion: There exists abnormal brain iron deposition before subclinical period in PD． The sites of pathologic iron deposition include SNc, SNr and RN, but not include GP, PUT, CN, THA and FWM.
Key words
Parkinson diseases /
Magnetic resonance imaging
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WANG Bo;MA Sha;DAI Min-fang;AN Hong-fei;WANG Yun-yong;ZHANG Jie;SHEN Ling.
A susceptibility weighted imaging quantitative study of brain iron deposition in idiopathic Parkinson’s disease[J]. Journal of China Clinic Medical Imaging. 2013, 24(4): 234-238
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