Pleomorphic xanthoastrocytoma: a report of 5 cases with MRI analysis and literature review

KANG Hou-yi; LIU Cai-bao; LI Xiao-guang; ZHANG Yu-long; ZHANG Wei-guo

Journal of China Clinic Medical Imaging ›› 2013, Vol. 24 ›› Issue (5) : 309-313.

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Pleomorphic xanthoastrocytoma: a report of 5 cases with MRI analysis and literature review

KANG Hou-yi, LIU Cai-bao, LI Xiao-guang, ZHANG Yu-long, ZHANG Wei-guo

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Abstract

Objective: To investigate the features and clinical application of MRI on pleomorphic xanthoastrocytoma. Methods: The conventional and functional MRI of five cases with pleomorphic xanthoastrocytoma confirmed by surgery and pathology were analyzed retrospectively. Results: Four cases showed solid and cystic lesions in the cortical-subcortical regions and one case showed insular cortex solid mass, most of which were surrounded by mild edema. Moreover, the mural nodule lesions or solid mass was obviously enhanced. DWI revealed low signal, PWI showed increased perfusion value (rCBV value of 2.96±0.64), and MRS showed that the Cho/NAA peak ratio(2.03±1.08) and Cho/Cr peak ratio(1.77±0.69) were elevated, however, the NAA/Cr peak ratio was decreased(0.94±0.38). The follow-up observation revealed that only one case with malignant signs in imaging findings had recurrence, and the prognosis of the other patients was good. Conclusions: Conventional and functional MRI have characteristics for pleomorphic xanthoastrocytoma diagnosis, and functional imaging may provide a prognostic information. To understand the features correctly may improve the diagnostic accuracy and guide the clinical treatment for pleomorphic xanthoastrocytoma.

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Astrocytoma / Magnetic resonance imaging

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KANG Hou-yi;LIU Cai-bao;LI Xiao-guang;ZHANG Yu-long;ZHANG Wei-guo. Pleomorphic xanthoastrocytoma: a report of 5 cases with MRI analysis and literature review[J]. Journal of China Clinic Medical Imaging. 2013, 24(5): 309-313