Abstract
Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods: Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook 1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased, NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.
Key words
Diffuse axonal injury /
Magnetic resonance spectroscopy
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QI Qiang;ZOU Yu-lin;TAO Jin-de;LIU Xiao;LI Zhi-juan;CHEN Zhen-ping;LI Xing-fu;WU Hui-qin.
Correlation study of MRS diagnosis of diffuse axonal injury with clinical prognosis[J]. Journal of China Clinic Medical Imaging. 2014, 25(11): 761-763
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