Research in the relationship between the contrast-enhanced ultrasound images and expression of C-erbB-2, nm23 in breast cancer

LIU Jian; GAO Yun-hua; AN Shao-yu; GAO Yan-chun; ZHAO Xiao-bo; HE Li

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (11) : 764-767.

论著

Research in the relationship between the contrast-enhanced ultrasound images and expression of C-erbB-2, nm23 in breast cancer

LIU Jian1, GAO Yun-hua1, AN Shao-yu2, GAO Yan-chun2, ZHAO Xiao-bo2, HE Li2

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Abstract

Objective: To discuss the relationship between the contrast-enhanced ultrasound(CEUS) images of the breast cancers and the molecular biology markers of C-erbB-2 and nm23. Methods: The imaging data of CEUS in breast cancer, C-erbB-2 and nm23 immunohistochemical results after operation were analysed retrospectively. Correlation between CEUS indexes or parameters and the expression of C-erbB-2 and nm23 were also studied. Results: ①The positive expression rate of C-erbB-2 and nm23 in breast cancer were 66.7%(46/69) and 27.5%(19/69) respectively. The positive expression of nm23 in the group with C-erbB-2 positive expression was 13%, which was higher than that in the group with C-erbB-2 negative expression. ②In the group with C-erbB-2 positive expression, lesions showed high enhancement, heterogeneous enhancement or lesions with perfusion defect area, peripheral radial enhancment, relative rising slope and relative peak intensity showed significant differences in the time intensity curves, compared with the group with C-erbB-2 negative expression(P<0.05). ③In nm23 negative group, the lesion showed high enhancement, peripheral radial enhancement, and the time intensity curve showed higher relative rising slope with statistical significance(P<0.05) compared with the nm23 positive group. Conclusion: Some contrast-enhanced ultrasound features correlated with C-erbB-2 and nm23 expression in breast cancer, which could be useful to predict the prognosis of patients to some extent.

Key words

Breast neoplasms / Ultrasonography / Doppler / color

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LIU Jian;GAO Yun-hua;AN Shao-yu;GAO Yan-chun;ZHAO Xiao-bo;HE Li. Research in the relationship between the contrast-enhanced ultrasound images and expression of C-erbB-2, nm23 in breast cancer[J]. Journal of China Clinic Medical Imaging. 2014, 25(11): 764-767