A voxel-based MRI morphometric study of Parkinson’s disease

DING Hong-bin; TIAN Wei-zhong; ZHANG Ji; CHEN Xiao-yun; XIA Jian-guo; ZHAO Jin-li; GU Hong-mei

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (3) : 158-161.

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A voxel-based MRI morphometric study of Parkinson’s disease

DING Hong-bin1, TIAN Wei-zhong1, ZHANG Ji1, CHEN Xiao-yun1, XIA Jian-guo1, ZHAO Jin-li2, GU Hong-mei2

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Abstract

Objective: To investigate the abnormal region of gray matter and its’ distribution in Parkinson’s disease(PD) patients using voxel-based morphometry(VBM) method. Method: Twenty-five cases of clinically defined PD patients and 23 cases of healthy controls received MR scan on 3.0T MR system. The T1WI data were collected. Using VBM method to compare the images of brain gray matter between two groups. The results were shown by statistical parametric mapping. Result: PD patients showed extensively decreased gray matter volume in widespread brain regions involving bilateral insular, parahippocampal gyrus, amygdale and right frontal, temporal, occipital, parietal lobes and left medial frontal gyrus. Conclusion: The VBM could thoroughly and accurately reflect the abnormal area of brain gray matter quantitatively which were common in PD patients, and it also provided the necessary neural imaging evidence for the pathological mechanism of PD patients with multiple system involvement.

Key words

Parkinson disease / Diffusion magnetic resonance imaging

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DING Hong-bin;TIAN Wei-zhong;ZHANG Ji;CHEN Xiao-yun;XIA Jian-guo;ZHAO Jin-li;GU Hong-mei. A voxel-based MRI morphometric study of Parkinson’s disease[J]. Journal of China Clinic Medical Imaging. 2014, 25(3): 158-161