Molecular imaging of aquaporin by DWI-MRI with multiple b values: mechanism and method

LI Jia-hui; LI Qiu-ju; YU Bing; ZHANG Xin; ZHAO Zhou-she; SHI Yu; XIN Jun; GUO Qi-yong

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (3) : 186-189.

论著

Molecular imaging of aquaporin by DWI-MRI with multiple b values: mechanism and method

LI Jia-hui1, LI Qiu-ju1, YU Bing1, ZHANG Xin1, ZHAO Zhou-she2, SHI Yu1, XIN Jun1, GUO Qi-yong1

Author information +

History +

Abstract

Objective: To study the mechanism and method of molecular imaging of aquaporin by DWI-MRI with multi-b-values. Materials and Methods: On 3T MRI, multi-b-value(0~4 500 s/mm2) DWI was performed for water, contrast agent, whole blood, plasma and red blood cells using acetazolamide as an inhibitor of water channel protein on red cell membrane. Effects of the inhibitor on red blood cell morphology and signal variation of different tissues in multi-b-value imaging were observed. Results: Acetazolamide increased the diameter of red blood cell by more than 10%. B value in the range of 0~200 s/mm2 could distinguish different tissues. B value in the range of 300~1 500 s/mm2 couldn’t distinguish different tissues. When b value was greater than 1 700 s/mm2, it showed the information of water channel protein on red cell membrane. Conclusion: In DWI-MRI with multiple b values, low b value imaging has tissue specificity, but high b value can achieve aquaporin molecular imaging.

Key words

Acetazolamide / Diffusion magnetic resonance imaging

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LI Jia-hui;LI Qiu-ju;YU Bing;ZHANG Xin;ZHAO Zhou-she;SHI Yu;XIN Jun;GUO Qi-yong. Molecular imaging of aquaporin by DWI-MRI with multiple b values: mechanism and method[J]. Journal of China Clinic Medical Imaging. 2014, 25(3): 186-189