Quantitative analysis of early liver fibrosis in rats by 13N-NH3·H2O PET/CT

HAN Ting-ting; DU Ming; ZHANG Xin; CAO Li; LI Hong; ZHAO Zhou-she; XIN Jun; GUO Qi-yong

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (4) : 243-247.

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Quantitative analysis of early liver fibrosis in rats by 13N-NH3·H2O PET/CT

HAN Ting-ting1, DU Ming1, ZHANG Xin1, CAO Li1, LI Hong2, ZHAO Zhou-she2, XIN Jun1, GUO Qi-yong1

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Abstract

Objective: To investigate the value of 13N-NH3·H2O PET/CT in quantitative diagnosis of early liver fibrosis. Methods: Using 13N-NH3·H2O as imaging agent and acetazolamide(ACZ) as inhibitor, 5 rats of control group and 12 rats of liver fibrosis(7 of stage S1 and 5 of stage S2+S3+S4) undertook dynamic PET/CT scan. With data reconstruction and imaging analysis, we calculated the uptake rate of 13N-NH3·H2O by livers in the two groups at time points of 20 s, 90 s, 5 min, 10 min, 15 min, 20 min and 25 min. Blood perfusion, interstitial diffusion and 13N-NH3·H2O uptake were compared between the two groups at different time points. Results: The SUV of S0 at time points of 10 min and 15 min, S1 at 20 s, S2+S3+S4 at 10 min, 15 min, 20 min and 25 min showed statistical difference before and after using the inhibitor(ACZ). The SUV of each group at any time point had no obvious difference. Conclusion: 13N-NH3·H2O PET/CT combined with ACZ can diagnose early liver fibrosis and staging of liver fibrosis.

Key words

Liver cirrhosis / Positron-emission tomography / Tomography / X-ray computed / Rats

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HAN Ting-ting;DU Ming;ZHANG Xin;CAO Li;LI Hong;ZHAO Zhou-she;XIN Jun;GUO Qi-yong. Quantitative analysis of early liver fibrosis in rats by 13N-NH3·H2O PET/CT[J]. Journal of China Clinic Medical Imaging. 2014, 25(4): 243-247