Research on producing fully automated one-step (11C) labeled water channel protein inhibitor, the imaging agent

CAO Li; DU Ming; ZHANG Xin; LI Hong-li; HAN Ting-ting; ZHAO Zhou-she; XIN Jun; GUO Qi-yong

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (5) : 344-346.

论著

Research on producing fully automated one-step (11C) labeled water channel protein inhibitor, the imaging agent

CAO Li1, DU Ming1, ZHANG Xin1, LI Hong-li2, HAN Ting-ting1, ZHAO Zhou-she2, XIN Jun1, GUO Qi-yong1

Author information +

History +

Abstract

Objective: To research and synthesize the fully automated one-step (11C) labeled water channel protein(AQP) inhibitor, the imaging agent. Materials and Methods: Using the TRACERlab FXC synthesis platform, under 100℃ reaction conditions in alkaline conditions (11C) CH3I reacted with acetazolamide. Then using sodium biphosphate as eluent, through high performance liquid chromatography(HPLC), (11C)N-methylacetazolamide was isolated from reaction solution. Results: The synthesis efficiency of the agent was above 50%, the radiochemical purity was over 98%, the time for the whole producing process was only about 30 min. After intravenous injection of (11C)N-methylacetazolamide into the tail vein of rat, and performing PET/CT scanning, the distribution of the above agent can be seen in rats, after injection of (11C)N-methylacetazolamide and N-methylacetazolamide, the inhibitor, the (11C)N-methylacetazolamide decreased significantly in the rat is liver. Conclusion: This is the first study and report on development of the fully automated one-step (11C) labeled water channel protein(AQP) inhibitor. The (11C)N-methylacetazolamide can be used as AQP PET tracer agent.

Key words

Radiopharmaceuticals / Acetazolamide / Positron-emission tomography

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

CAO Li;DU Ming;ZHANG Xin;LI Hong-li;HAN Ting-ting;ZHAO Zhou-she;XIN Jun;GUO Qi-yong. Research on producing fully automated one-step (11C) labeled water channel protein inhibitor, the imaging agent[J]. Journal of China Clinic Medical Imaging. 2014, 25(5): 344-346