The role of SWI in detecting the number of Gamna-Gandy bodies in spleen and its relationship with portal hypertension

TAO Ran; CUI Jin-guo; YUAN Hong-li; ZHOU Xiang-jun; TIAN Fu-cun; ZHANG Jiu-quan; WANG Jian

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (6) : 397-401.

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The role of SWI in detecting the number of Gamna-Gandy bodies in spleen and its relationship with portal hypertension

TAO Ran1, CUI Jin-guo1, YUAN Hong-li1, ZHOU Xiang-jun2, TIAN Fu-cun2, ZHANG Jiu-quan3, WANG Jian3

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Abstract

Objective: To detect Gamna-Gandy bodies(GGB) in spleen with susceptibility-weighted imaging(SWI) and to evaluate the potential role of GGB number as a non-invasive marker of portal hypertention(PH). Methods: SWI and conventional T1-, T2- and coronal T2-weighted imaging were performed on 135 patients with PH and on 37 control individuals. Platelet counts were collected from all PH patients. The portal vein diameter, splenic index(SI), and platelet count/splenic length ratio were measured. The GGB numbers were counted on representative slice of SWI sequence in GGB-positive patients. The portal vein diameter, SI, platelet count, and platelet count/splenic length ratio of control individuals were compared with those of GGB-negative and GGB-positive patients on SWI images. The correlations among GGB numbers, the portal vein diameter, the SI, the platelet count, and the platelet count/splenic length ratio were analyzed. Results: The GGB detection rate was 37.8%(51/135). The number of GGB detected on representative slice of SWI was 40.9±28.4. The portal vein diameter, SI, platelet count, and the platelet count/splenic length ratio of GGB-positive patients were significantly higher(or lower) than that in the controls and GGB-negative patients. The number of GGB in the SWI images correlated positively with the portal vein diameter and SI, and correlated negatively with the platelet count and platelet count/spleen diameter ratio. Conclusion: The number of GGB on SWI may be a non-invasive marker for grading of PH.

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Hypertension / portal / Liver cirrhosis / Magnetic resonance imaging

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TAO Ran;CUI Jin-guo;YUAN Hong-li;ZHOU Xiang-jun;TIAN Fu-cun;ZHANG Jiu-quan;WANG Jian. The role of SWI in detecting the number of Gamna-Gandy bodies in spleen and its relationship with portal hypertension[J]. Journal of China Clinic Medical Imaging. 2014, 25(6): 397-401