Neuroimaging diagnostic value of intraaxial reversible focal isolated lesions in the splenium of the corpus callosum

ZHENG Kui-hong; MA Lin; WANG Ya-ming; HUANG Min-hua; WANG Zi-jun; SHAO Li-xin; YING Li-gang

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (7) : 457-459.

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Neuroimaging diagnostic value of intraaxial reversible focal isolated lesions in the splenium of the corpus callosum

ZHENG Kui-hong1, MA Lin2, WANG Ya-ming1, HUANG Min-hua1, WANG Zi-jun1, SHAO Li-xin1, YING Li-gang1

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Abstract

Objective: A focal isolated lesion in the splenium of the corpus callosum(SCC) is a rare finding in MRI. The aim of the present study was to describe MR imaging findings of the SCC lesion and to analyze the relationship between this lesion and possible etiologic factors. Methods: Three patients with SCC lesion on MRI were reviewed. The imaging findings on MRI were analyzed. The clinical records and literature were also reviewed. Results: The first patient with influenza presented with mental symptom showed a lesion in the central portion of the splenium. After receiving antiviral medication, his neurological deficits completely recovered, and the diagnosis of virus-associated encephalitis was made. Two weeks later, the lesion completely disappeared. The second patient with epilepsy presented with signal abnormalities in the SCC in the context of presurgical epilepsy, the patient had received antiepileptic drugs for years. One week after operation for epilepsy, MR examination showed a clear reduction in lesion size. The last patient presented with abnormal neurological findings, and MRI showed an isolated SCC lesion and diffuse abnormal intensity in spinal cord. The diagnosis of acute disseminated encephalomyelitis(ADEM) was made and the recovery was complete in one month. Follow-up MR examinations showed complete disappearance of the SCC lesion. Conclusion: There is not a single condition or disease responsible for SCC lesion. These lesions are detected in a relatively large number of conditions with heterogeneous etiopathogenetic factors and a focal SCC lesion on MRI is a nonspecific finding.

Key words

Encephalitis / Corpus collosum / Magnetic resonance imaging

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ZHENG Kui-hong;MA Lin;WANG Ya-ming;HUANG Min-hua;WANG Zi-jun;SHAO Li-xin;YING Li-gang. Neuroimaging diagnostic value of intraaxial reversible focal isolated lesions in the splenium of the corpus callosum[J]. Journal of China Clinic Medical Imaging. 2014, 25(7): 457-459