Clinical and MRI diagnosis of hemimegalencephaly: report of 5 cases with literature review

LIU Zhai; HE Li; WANG Wei-xiu; REN Qing-yun

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (8) : 538-541.

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Clinical and MRI diagnosis of hemimegalencephaly: report of 5 cases with literature review

LIU Zhai1, HE Li1, WANG Wei-xiu2, REN Qing-yun1

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Abstract

Objective: To investigate the clinical and MRI features of hemimegalencephaly(HME). Methods: The clinical and MRI findings of 5 cases with HME were reviewed retrospectively, at the same time literature review was carried out. Results: Epilepsy was found in 3 cases, hemi-hypertrophy of extremities found in 3 cases, mental retardation in 2 cases. MRI showed enlargement of the affected cerebral hemisphere, apparent thickening of the grey matter, and poor grey/white differentiation in all 5 cases. Involvement of left cerebral hemisphere in 3 cases and right hemisphere 2 cases. Enlargement of the ipsilateral ventricle was seen in all cases, straightening of the forntal horn of the ipsilateral ventricle in 2 cases and colpocephaly in 1 case. Three cases had hyper-intensity in the white matter of the affected hemisphere. Conclusion: There is characteristic MRI features of HME. MRI demonstrates diffuse hypertrophy of the affected hemisphere, ipsilateral ventricle dilatation, thickened cortex, and hyperintensity of the white matter.

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Nervous system malformations / Magnetic resonance imaging

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LIU Zhai;HE Li;WANG Wei-xiu;REN Qing-yun. Clinical and MRI diagnosis of hemimegalencephaly: report of 5 cases with literature review[J]. Journal of China Clinic Medical Imaging. 2014, 25(8): 538-541